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Meeting:
Prerequisite:
Credit
Hours:
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Thursdays,
10:00 am- 12:00 pm
E15-054
Permission of instructor
9 units
H-Level
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This
course explores recent developments at the interface of nanotechnology,
surface chemistry, and biology. The course begins with introductory
lectures on silicon fabrication, chemistry, and molecular biology
and continues with a series of in-depth lectures on field-effect
devices, solid-liquid interfaces, techniques for surface analysis
and modification, nanopore characterization of biopolymers, and
protein microarrays. The final section of the class will focus on
using biology to build molecular machines, molecular assemblers,
and computers.
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Outline
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Sept
6 |
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Micro-
and nanofabrication |
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Sept
13 |
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Mechanical
biosensors |
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Sept
20 |
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Field-Effect
Sensors |
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Sept
27 |
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Solid
- Liquid Interface |
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Oct
4 |
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Surface
Analysis and patterning |
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Oct
11 |
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Protein
microarrays |
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Oct
18 |
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Nanochemistry
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Oct
25 |
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New
Understandings in Molecular Biology |
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Nov
1 |
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BioAssemblers
and Bio-Molecular
Machines |
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Nov
8 |
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The
Genetic Switch |
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Nov
15 |
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The
Immune System |
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Nov
29 |
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Strategies
Against Disease |
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Dec
6 |
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Nueronal
Logic |
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Dec
11 |
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Final
Project |
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Class
Schedule
10 - 10:15 Problem set, 10:15 - 11:45 Lecture, 11:45
- 12:30 Research presentations
(lunch will be served at 11:45)
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Grading
50% class participation, 50% final project
Problem
Sets
Problem sets will be handed out on a weekly basis and volunteers
will be selected to present selected problems during the first 15
minutes of each class. Students are encouraged to work in teams.
Please make sure to arrive a few minutes before 10am.
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Final
Project Description
Each team will be required to generate a novel proposal in an area
of relevance to the domain of the course. The proposal should be
described in sufficient detail (i.e. design, fab steps, chemical
synthesis) to actually carry out the proposal. The deliverable for
the final project is a powerpoint presentation (10-15 slides) laying
out the basic proposal, what problem the proposal addresses or solves,
experimental detail for how the proposal will be brought into reality
and potential impact and applications of the proposal. Each team
will present their proposal on Final Project Day, Tuesday, December
11th.
Teams
are strongly encouraged to pursue projects which are either 1] Disruptive
in nature and change some fundamental paradigm in the field (i.e.
sequence the genome in a day, amplify proteins etc.) or 2] Can be
backed up with actual experimental results or preliminary demonstration
of the proposal.
Target
team size is four people with the requirement that at least one
of the team members come from a different technical backgrounds
(i.e. two people from engineering and two from biology). Teams are
required to submit a list of team members and a one paragraph project
summary by November 8th.
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